Category Archives: 2021

March 2nd, 2021 – Dr Maryna Basalay from the Hatter Cardiovascular Institute at UCL, awarded as 2021 Paul Dudley White International Scholar

The American Heart Association has recognised the research excellence of Dr Maryna Basalay by announcing her as the 2021 Paul Dudley White International Scholar. This award recognizes all the authors that contributed to the highest ranked abstract from each country; the abstract submitted by Dr Basalay and the team at the Hatter Cardiovascular Institute being the highest ranked abstract submitted from the United Kingdom.

Dr Basalay is the lead for the Neuroprotection research programme at the Hatter Cardiovascular Institute investigating mechanisms to protect the brain from ischaemic stroke. Despite only starting 3 years ago, Dr Basalay has undertaken a substantial amount of research that has enabled us to understand the complexities of neuroprotection.

The Hatter Cardiovascular Institute is very proud of this achievement by Maryna and the whole team and looks forward to seeing further research excellence from this programme.

Dr Basalay will present her abstract to the International Stroke Conference which taking place as a virtual event in March.

To view the award, please click here.

February 9th, 2021 – WEBINAR: The importance of SGLT2 inhibitors & GLP-1 analogues in the management of type 2 diabetes and cardio-renal disease

The Hatter Cardiovascular Institute at University College London is hosting a webinar to discuss & debate SGLT2 inhibitors & GLP-1 analogues in the management of Diabetes & Cardio-Renal disease.

Recognising the importance of informing clinical trainees early in their careers, this is one of a series of meetings created to address this need. Trainees (SpR’s) in the specialities of Cardiology, Nephrology and Diabetes are invited to attend this webinar with leaders in all three fields presenting specific to the topic area in a clinical setting.

To attend, all interested trainees simply need to register their interest and join us on FRIDAY the 19th MARCH, 2021 from 10am -12pm (GMT) for the webinar which should last approximately 2 hours. THERE IS NO CHARGE TO ATTEND.

Please register for the webinar here:

https://ucl.zoom.us/meeting/register/tJAtde-trToiEtRPj91GyS2xOzwN05ukUgkD


Webinar Chairpersons:
Professors Derek Yellon, John Cunningham & Stephanie Baldeweg

PROGRAMME:

1. Management of type 2 diabetes – out with the old & in with the new!
Professor Stephanie Baldeweg
University College London, UK

2. New anti-diabetic therapy – their role in renal protection.
Professor David Wheeler, UK
The Royal Free Hospital, University College London

3. The GLP-1 analogues – their role in obesity.
Professor John Wilding
University of Liverpool, UK

4. SGLT2 inhibitors – their role in heart failure.
Professor Theresa McDonagh
Kings College, London, UK

5. SGLT2 inhibitors & GLP-1 analogues – do we understand the mechanisms?
Dr Robert Bell
The Hatter Cardiovascular Institute, University College London, UK

Short concluding responses from SpR’s in Cardiology, Nephrology and Diabetes:
Dr Sarah Qian – SpR in Diabetes
Dr Ali Rauf – SpR in Cardiology
Dr Tamer Rezk – SpR in Nephrology

February 4th, 2021 – Hatter Cardiovascular Institute COVID-19 Research Study Expands Globally

Following approval in April 2020, The Hatter Cardiovascular Institute (HCI) has been undertaking a study in COVID-19 investigating the potential for Remote Conditioning (RIC) to reduce the severity of anti-inflammatory cytokines which are responsible for the so-called cytokine “storm” that occurs in COVID-19 patients. The study, titled ‘Can Remote Ischaemic Conditioning Reduce Inflammatory Markers in COVID-19 Patients – A   Randomised Pilot Study,’ was initially approved at University College London Hospitals but has since been expanded to two additional sites in the UK, the Royal Free Hospital (London) and the Lister Hospital (Stevenage).

In further development, the HCI has forged strong collaborations with two leading teams in South Africa and Brazil to investigate in parallel the use of RIC in COVID-19 patients in their populations. Prof Andrei Sposito is the study lead at the University of Campinas, Brazil and Prof Mpiko Mpiko Ntsekhe is heading up the study at the University of Cape Town, South Africa.

 Both South Africa and Brazil find themselves in the similar situation as the UK with extremely high cases of COVID-19 and subsequent deaths. It is the hope of all three study teams that by combining data from our shared protocols, we can develop a new method to reduce the heightened inflammatory response and halt the progression of COVID-19 in patients and reduce the severity of damage, with the ultimate aim of preventing deterioration of patients into intensive care.

February 2nd, 2021 – New CAR T Cell Therapy Study Initiated to Investigate Cardiovascular Outcomes

A new study to investigate the cardiovascular outcomes of patients receiving CAR (CD19-specific chimeric antigen receptor) T cell therapy for the treatment of relapsing or refractory (not responsive to other treatments) blood cancers is now underway at The Hatter Cardiovascular Institute.

CAR T cells are a novel therapy for relapsing or refractory blood cancers, which have delivered a significant improvement in the rates of complete and partial cancer remission. However, they are associated with toxicities, with some of early evidence suggestive of cardiovascular involvement. Despite this, the full extent of cardiovascular toxicity is poorly understood.

This research study, led by Dr Daniel Chen, Prof Malcolm Walker and Prof Derek Yellon, seeks to understand the cardiac safety of CAR T cells in patients who receive this therapy as part of standard care for relapsed/refractory B-cell blood cancer. Patients will be assessed for cardiovascular risk factors using blood biomarkers and cardiovascular imaging such as echocardiographs and MRI. The aim is to be able to accurately predict the patient cohort most at risk of cardiovascular toxicity and define the cardiac safety of CAR T cell therapies.

The study is now active and recruitment will occur over the next 12 months in collaboration with University College London Hospitals Macmillan Cancer Centre. Cardio-Oncology is a rapidly emerging and increasingly important field of medicine and this study will contribute further knowledge to the cardiac care of cancer patients.