January 28th, 2020 – Another Successful Series of Medical Educational Meetings for the Hatter Cardiovascular Institute, UCL

The Hatter Cardiovascular Institute recently hosted a series of medical educational meetings to discuss new developments in the management of diabetes & cardiovascular disease. Audiences included researchers, primary care physicians and specialists clinicians. An area of interest was the new therapeutic agents including SGLT2 inhibitors and GLP-1 analogues.

The 2 Horizon series of meetings addressed diabetes management from multi-disciplinary perspectives bringing together Nephrology, Cardiology and Diabetology for comprehensive discussions. One meeting was held specifically for an audience of Primary Care Physicians while a second was directed to Specialist Clinicians.

Recognising the importance of informing clinical trainees early in their careers, a newly created series of Hatter Institute Scientific Meetings was created to address this need. Therefor in a  third meeting, Trainees (SpR’s) in the specialities of Nephrology, Diabetes and Cardiology were invited to attend and found the day both beneficial to their area of interest but also for the ability to network with their colleagues in other disciplines who they might not otherwise meet, stimulating future multi-disciplinary teams.

Feedback from the above meetings was very positive and will help to guide further meetings later this year. We are grateful that those attending found these workshops so informative. We strive to create engaging programmes to disseminate the latest developments to benefit working practice and knowledge amongst the medical community.

Feedback reports from each of the 3 meetings can be found below:

HATTER HORIZON MEETING FEEDBACK REPORT_CLINICIAN_DEC19

HATTER HORIZON MEETING FEEDBACK REPORT_GP__DEC19

HATTER SCIENTIFIC MEETING FEEDBACK REPORT_TRAINEE_JAN20

Dates for upcoming Horizon and Hatter Scientific Workshops will be announced shortly.

January 24th, 2020 – Cardio-Oncology Consultant Leading in Education & Training

The Hatter Cardiovascular Institute is at the forefront of cardio-oncology research. With awareness of the detrimental effects chemotherapy has on a patient’s heart, this rapidly evolving field of medicine aims to develop new methods to detect cardiovascular damage and subsequently provide protection during treatment.

We are pleased to congratulate one of our leading Cardio-Oncology Consultants, Dr Arjun Ghosh, on his recent accomplishments in leading the national and global education and training initiatives in this area. These include:

*Newly appointed member of the International Cardio-Oncology Society Training and Education Advisory Committee

*Lead –  British Society of Echocardiography guidelines in Cardio-Oncology

*Lead – UK Cardio-Oncology curriculum design

*Lead – Education and Training at the British Cardio-Oncology Society

*Lead – UK’s first and only national Cardio-Oncology Course which has now become a BCS course

*Organiser – Europe’s first and only Cardio-Oncology Course

*Member – ESC Council of Cardio-Oncology

Dr Ghosh recently visited the Tata Medical Centre in Kolkata, a tertiary cancer centre of excellence providing care to patients across India, Bhutan, Nepal and Bangladesh. With a cardio-oncology service in early development, Dr Ghosh was pleased for the opportunity to assist in the education and training to the team there as they work towards establishing a more permanent clinical service. Details of this visit can be seen HERE.

To promote continued progress in Cardio-Oncology, Dr Ghosh leads on clinical trials, participates in multidisciplinary committees and presents regularly across the UK and internationally.

January 10th, 2020 – Cardiovascular Clinical Fellowships

UCL and the Wellington Hospital are recruiting to a Fellowship scheme in which Fellows study for a PhD in the UCL Institute of Cardiovascular Science while working at the UK’s largest private hospital providing specialist complex care.

Fellows register part-time at UCL and the Wellington pays their salary (£45,000 pa), the annual fees which will include a budget for consumables and activities. In return the Fellows are employed directly by the Hospital, working the equivalent of 30 hours per week.

Clinically the Fellows will be based at the Wellington Hospital in St. John’s Wood, London while the academic work will be based within the Institute of Cardiovascular Science, UCL.

We welcome all applicants who are medically qualified, GMC registered and have MRCP. The scheme is open only to UK/EEA nationals due to funding restrictions.

To apply, please visit one of the links below:

UCL

JOBS.AC.UK

Closes: 9th February 2020

Start Date: October 2020

December 10th, 2019 – Another Successful Year for Post Graduate Education at the Hatter Cardiovascular Institute

2019 has been another successful year for post graduate students at the Hatter Cardiovascular Institute (HCI). This year 3 PhD’s and 1 MD(Res) were awardee to members of the HCI. This brings the total number of higher degrees emanating from the HCI to 70.

The Hatter Cardiovascular Institute is pleased to congratulation the following recipients from 2019:

Dr Stasa Taferner  PhD – An investigation into the role of the CXCR7 chemokine receptor in acute MI and angiogenesis.

Dr Idris Harding PhD – Determinants of Reperfusion Injury in the Diabetic Heart

Dr Kaloyan Takov PhD – Cardioprotective & proangiogenic activities of small exosomes released by amniotic fluid stem cells.

 Dr Ashraf Hamarneh MD(res) – The effect of RIC and glyceryl trinitrate on perioperative myocardial injury in CABG patients.

December 6th, 2019 – The Hatter Cardiovascular Institute Amongst Top Ranking Highest Cited Articles

Cardiovascular Diagnosis and Therapy has published their list of top ranking highest cited 2016-2017 articles for the impact factor year 2018. The Hatter Cardiovascular Institute was recognised with 2 papers on this list, attesting to the novel research and continuing contribution to cardiovascular scientific knowledge of our team.

The papers of note are:

Anthracycline Chemotherapy and CardiotoxicityJ.V. McGowan, R. Chung, A. Maulik, I. Piotrowska, M.J. Walker, D.M. Yellon, Issue 31:1 (2017)

Total Citations: 101            Citations 2018: 51

 Exosomes and Cardiovascular ProtectionS.M. Davidson, K. Takov, D.M. Yellon, Issue 31:1 (2017)

Total Citations: 23            Citations 2018: 14

 Many congratulations to our team for this recognition of their ongoing hard work.

October 9th, 2019 – Dr Catherine Wilder Awarded Fast Track Grant

The Hatter Cardiovascular Institute is pleased to congratulate Dr Catherine Wilder on her success in the recent call for Fast Track grants. Competing against many strong applications, Dr Wilder’s project ‘Gasdermin D – a novel target for dual protection against acute and chronic effects of cardiac ischaemia and reperfusion injury in human myocardium?’ was awarded £39,640.

Dr Wilder will use these funds to continue her research in this emerging area of cardiovascular science over the next year with the aim of producing strong pilot data to enable a further application to an external funder for a larger, more strategic award.

The Fast Track scheme is a collaboration between the NIHR University College London Hospitals Biomedical Research Centre and the UCLH Charity.

Congratulations Dr Wilder!

September 6th, 2019 – The Hatter Cardiovascular Institute at UCL Announces the Outcomes of CONDI2/ERIC-PPCI Study at European Society of Cardiology Congress in Paris

Initiated in 2015, the ERIC-PPCI study was a multicentre, randomised double blind placebo controlled clinical trial investigating whether remote ischemic conditioning (RIC) can reduce cardiac death and hospitalization for heart failure at 12 months in patients presenting with a ST-elevation myocardial infarction (STEMI) and treated by percutaneous coronary intervention (PPCI). The study was undertaken in collaboration with the CONDI2 trial (Denmark, Serbia and Spain) and recruited 5401 patients in total, across 33 centres.

Importantly this landmark study has revealed the RIC procedure has a neutral outcome for the patients enrolled.

The Hatter Cardiovascular Institute has led the study from inception with Prof Derek Yellon and Prof Derek Hausenloy as Principal Investigators together with Prof Erik Bøtker from Denmark and Prof Raj Kharbanda from Oxford.  This study represents a true translational investigation as the basic scientific research began in the laboratories of the Hatter Cardiovascular Institute, through to “proof of concept” at University College London Hospitals and finally resulting in this large scale, clinical study in man.

While the outcome has shown a neutral effect, this is a definitive answer to the question driving the study, the ultimate goal for all scientific research we undertake. From this result we are now able to formulate new hypotheses and look forward to understanding survival pathways and cellular mechanisms in humans. For example, the patients in the CONDI2/ERIC – PPCI study were from developed nations, namely the UK and Europe, typically on a regimen of medications which raise the threshold of protection alone. It may be that developing countries, with limited access to medical care and medications, are a more appropriate target for RIC in a STEMI setting. This outcome is important and discussions are already underway as to how to take this forward.

The PI’s of the study are grateful to all the patients who participated, the study team and the British Heart Foundation for their substantial support.

The full report of the study has been published in the Lancet, please read the paper HERE.

July 26th, 2019 – The Hatter Cardiovascular Institute Says Goodbye to Visiting Student

The Hatter Cardiovascular Institute was sad to say goodbye this week to Concepción Santiago, a Ph.D. student visiting from the Institute of Biomedical Research in Málaga, Spain, from the laboratory of Dr Edwardo Garcia Fuentes. Concepción was here for three months working under the supervision of Prof Sean Davidson on the question of how age and senescence affects exosomal nanoparticles. During her time with us she became one of the team and her collaborative work has been beneficial to the research here at the HCI. We wish her all the best in her continued studies towards achieving her Ph.D.